THE EBOLA CURE
A Nigerian doctor based in the United States, Maurice Iwu, has claimed that Garcinia kola, popularly called bitter cola in West Africa may be a possible drug against the deadly Ebola virus.
Bitter cola, a staple health fruit in Nigeria, was reported to have stopped the virus at test tube experiments. The virus has so far killed more than 600 victims since its outbreak in Guinea, with Nigeria’s only recorded death being that of Liberian consultant, Patrick Sawyer, who died in Lagos last week.
An Inquirer Washington Bureau reported Iwu who made this discovery, as saying that a cure could be sourced from the same African forests where the disease was identified.
Iwu is a doctor with a combination of folk-remedy expertise and a doctorate in Western pharmacology. He is also the Executive Director of the Bioresources Development and Conservation Programme, and a consultant at Walter Reed Army Hospital in suburban Washington. One of the top infectious-disease laboratories in the US was said to have tested the fruit, and said that it passed the crucial and difficult first hurdle.
A virus expert who heads the effort at the US Army Medical Research Institute of Infectious Diseases in Fort Detrick, Maryland, to find antiviral drugs to fight exotic diseases, John Huggins, said, “It certainly is a promising compound. So far, it’s made it through all the gates that it has been sent through.”
But there are many more tests to be done, first on mice in the next few months, and eventually primates, before it would be used on people, Huggins said.
Only one of 20 prospective drugs that pass the test-tube test makes it onto the market, so the odds are against the fruit, Huggins said. A Professor of Microbiology at Washington University in St. Louis, Lawrence Gelb, said, “I would be – and am – very sceptical. But you can’t be an outright cynic; eventually some (prospective drug) works.”
Fighting chance
The virus multiplies rapidly in the human body and quickly overwhelms it, and in advanced cases the patient develops high fever and severe bleeding. The Garcinia kola compound has been shown to halt multiplication of the virus in the laboratory. If repeated in humans, this would give the body a chance to fight off the virus.
The active compound is what is known as a dimeric flavonoid, which is two flavonoid molecules fused together.
Flavonoids are non-toxic and can be found in orange and lemon rinds as well as the colourings of other plants.
Drug hopes
The tests are in the early stages still, but the researchers hope that if they continue to prove successful the compound the US Food and Drug Administration will put it on a fast track – making a drug available to humans within a matter of years.
“The discovery of these important properties in a simple compound – flavonoids – was very surprising,” said Dr. Iwu.
“The structure of this compound lends itself to modification, so it provides a template for future work.
“Even if this particular drug does not succeed through the whole drug approval process, we can use it to construct a new drug for this deadly disease.”
The reason bitter kola may have an edge over other types of drugs that work in lab tests is that many drugs often prove toxic to people and animals in subsequent testing, whereas bitter cola has been used for centuries, and has gotten federal approval as a safe dietary supplement, Head of Applied Research at Missouri Botanical Garden, who has tried to develop plants as medicine in the past, Jim Miller, said.
Bitter cola, a staple health fruit in Nigeria, was reported to have stopped the virus at test tube experiments. The virus has so far killed more than 600 victims since its outbreak in Guinea, with Nigeria’s only recorded death being that of Liberian consultant, Patrick Sawyer, who died in Lagos last week.
An Inquirer Washington Bureau reported Iwu who made this discovery, as saying that a cure could be sourced from the same African forests where the disease was identified.
Iwu is a doctor with a combination of folk-remedy expertise and a doctorate in Western pharmacology. He is also the Executive Director of the Bioresources Development and Conservation Programme, and a consultant at Walter Reed Army Hospital in suburban Washington. One of the top infectious-disease laboratories in the US was said to have tested the fruit, and said that it passed the crucial and difficult first hurdle.
A virus expert who heads the effort at the US Army Medical Research Institute of Infectious Diseases in Fort Detrick, Maryland, to find antiviral drugs to fight exotic diseases, John Huggins, said, “It certainly is a promising compound. So far, it’s made it through all the gates that it has been sent through.”
But there are many more tests to be done, first on mice in the next few months, and eventually primates, before it would be used on people, Huggins said.
Only one of 20 prospective drugs that pass the test-tube test makes it onto the market, so the odds are against the fruit, Huggins said. A Professor of Microbiology at Washington University in St. Louis, Lawrence Gelb, said, “I would be – and am – very sceptical. But you can’t be an outright cynic; eventually some (prospective drug) works.”
Fighting chance
The virus multiplies rapidly in the human body and quickly overwhelms it, and in advanced cases the patient develops high fever and severe bleeding. The Garcinia kola compound has been shown to halt multiplication of the virus in the laboratory. If repeated in humans, this would give the body a chance to fight off the virus.
The active compound is what is known as a dimeric flavonoid, which is two flavonoid molecules fused together.
Flavonoids are non-toxic and can be found in orange and lemon rinds as well as the colourings of other plants.
Drug hopes
The tests are in the early stages still, but the researchers hope that if they continue to prove successful the compound the US Food and Drug Administration will put it on a fast track – making a drug available to humans within a matter of years.
“The discovery of these important properties in a simple compound – flavonoids – was very surprising,” said Dr. Iwu.
“The structure of this compound lends itself to modification, so it provides a template for future work.
“Even if this particular drug does not succeed through the whole drug approval process, we can use it to construct a new drug for this deadly disease.”
The reason bitter kola may have an edge over other types of drugs that work in lab tests is that many drugs often prove toxic to people and animals in subsequent testing, whereas bitter cola has been used for centuries, and has gotten federal approval as a safe dietary supplement, Head of Applied Research at Missouri Botanical Garden, who has tried to develop plants as medicine in the past, Jim Miller, said.
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